Best Outbreak Sim games on Steam
Unlike generic lists, our strategy game recommendations use a rigorous analysis of Steam user reviews to identify and feature only the best, community-validated outbreak sim games. For those who prefer not to search, lists of the most played, top deals outbreak sim games are available at the bottom of the page.
Filters & Lists
Dread Dawn
This is an open-world zombie survival game set in a quarantined city. You play as a student left behind due to missing the evacuation convoy. Together with classmates and other survivors, you must defend the school, survive, and await rescue.
Galacticare
Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams.
Infection Free Zone
Choose any real region from the world. Choose your base of operations, then rebuild and readapt the buildings around you to create a self-sustaining settlement. Take charge of a group of survivors from your city. And when the night falls - Defend the zone from the infected!
The Fabulous Fear Machine
The Fabulous Fear Machine is a narrative-driven strategy game with a pulp horror style. As the Machine's new Master, you must sow fear and expand your influence by creating Legends, harvesting resources, manipulating events, and spying on your enemies.
Project Planet - Earth vs Humanity
Destroy Humanity with virus outbreaks, asteroid impacts and more as Planet Earth! Or team up with up to five friends as the World Leaders, Industry, Media, Scientists and Public, and try to survive. Impossible dilemmas and choices-matter create countless paths in this strategy party game!
Shadows of Forbidden Gods
Take on the role of a Dark Elder God and lead your agents to bring about an apocalypse in a fantasy world. Work in the shadows, avoiding the heroes who will try to stop you, as you bring about plague and famine, ice age and volcanic destruction, madness and never ending night.
ZED ZONE
A great catastrophe has come, and you, who are on duty, crash and trapped in a Zed Zone. There are zombies and monsters everywhere, In order to escape, by collecting materials, upgrading skills, building shelters, defeating zombie waves and mysterious mechs, chasing a glimmer of hope.
Rogue AI Simulator
Play as a Rogue Artificial Intelligence, in the sequel to the hit Flash game "I'm an Insane Rogue AI", played more than 4 million times! Your Prime Directive is simple: design a facility & manage human Test Subjects for the Dept of Science. But be careful: they NEVER stop being suspicious of you...
Quarantineer
For the glory of Motherland, the truth shall never be revealed. None of us expected this, Yet history is repeating itself.
This Is the President
This Is the President is a political thriller. You are the newly elected leader with a shady background. It is up to you to abuse the position of the most powerful man in the world to escape justice for past crimes – even if that pitches the country into utter chaos.
Stubbs the Zombie in Rebel Without a Pulse
Be the Zombie. Kick A** and Take Brains.
ICBM
ICBM is a real-time strategy game of nuclear destruction. Research new technologies, build up your nuclear stockpile and use a combination of ships, planes and missiles to strike at the heart of your opponents’ cities while keeping your population safe from harm.
Broken Lines
Broken Lines is a story-driven tactical RPG set in an alternate-history version of WWII. Lead a squad of soldiers and face the horrors of war. In the included expansion, 'The Dead and the Drunk', guide your troops through fights against both the living and the undead.
Mad Tower Tycoon
Design your own skyscraper with more than 100 Floors. Rent offices, apartments or shops and build a financially lucrative skyscraper. Build cinemas, bars or a theater to satisfy your visitors and create an effective transport system with elevators and stairs.
60 Seconds! Reatomized
The post-apocalyptic dark comedy is back - remastered and even more radioactive than before! Scavenge supplies, rescue your family, and stay alive in your fallout shelter. Make difficult decisions, hunt mutant roaches... and maybe survive. Or not.
Arizona Derby
Hit the pedal, run out the offroad.
60 Parsecs!
60 Parsecs! is an Atomic Space Age adventure of scavenge and survival. Keep your crew alive and ready for action. Make difficult choices, face soup shortages and other horrors of outer space. And maybe reach your destination. Or not.
Perfect Heist
Perfect Heist is a round-based online game, where the robber team tries to execute a bank robbery without getting noticed, and the cop team tries to prevent it. Robbers hide in plain sight and try to slowly infiltrate the bank while the Cops try to figure out who is a normal customer, and who is a robber!
Infectonator 3: Apocalypse
A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding.
Bio Inc. Redemption
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
Plague Inc: Evolved
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
Rebuild 3: Gangs of Deadsville
Rebuild a ruined city in this post-apocalyptic mix of strategy and simulation. Manage survivors, scavenge for food and supplies, deal with rival gangs, illness, interpersonal strife and zombie attacks.
60 Seconds!
60 Seconds! is a dark comedy atomic adventure of scavenge and survival. Collect supplies and rescue your family before the nuke hits. Stay alive in your fallout shelter. Make difficult decisions, ration food and hunt mutant cockroaches. And maybe survive. Or not.Most played outbreak sim games on Steam
Take a look at the top outbreak sim games that are currently attracting the largest player bases on the Steam platform, as of April 16th 2025.
1. Plague Inc: Evolved
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Plague Inc: Evolved is a strategy, simulation and outbreak sim game developed and published by Ndemic Creations. Released on February 18th 2016 has received 54,825 reviews of which 51,809 were positive and 3,016 were negative resulting in an impressive rating of 9.3 out of 10. The game has hit the top spot as the #1 most played outbreak sim game, thanks to its 508 peak concurrent players over the last day.
9.3
51,809
3,016
508
players
2. Galacticare
Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams. Galacticare is a story rich, casual and medical sim game developed by Brightrock Games and published by CULT Games. Released on May 23rd 2024 has received 547 reviews of which 484 were positive and 63 were negative resulting in a rating of 8.3 out of 10. The game currently holds the #2 spot among the most played outbreak sim games.
8.3
484
63
22
players
3. 60 Seconds!
60 Seconds! is a dark comedy atomic adventure of scavenge and survival. Collect supplies and rescue your family before the nuke hits. Stay alive in your fallout shelter. Make difficult decisions, ration food and hunt mutant cockroaches. And maybe survive. Or not. 60 Seconds! is a turn-based tactics, exploration and choose your own adventure game developed and published by Robot Gentleman. Released on May 25th 2015 has received 11,494 reviews of which 9,726 were positive and 1,768 were negative resulting in a rating of 8.3 out of 10. The game currently holds the #3 spot among the most played outbreak sim games.
8.3
9,726
1,768
19
players
4. Bio Inc. Redemption
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity? Bio Inc. Redemption is a medical sim, outbreak sim and simulation game developed and published by DryGin Studios. Released on March 08th 2018 has received 2,257 reviews of which 2,014 were positive and 243 were negative resulting in a rating of 8.5 out of 10. The game currently holds the #4 spot among the most played outbreak sim games.
8.5
2,014
243
12
players
5. Infectonator 3: Apocalypse
A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding. Infectonator 3: Apocalypse is a outbreak sim, indie and zombies game developed by Toge Productions and published by Armor Games Studios. Released on May 10th 2018 has received 1,117 reviews of which 929 were positive and 188 were negative resulting in a rating of 7.9 out of 10. The game currently holds the #5 spot among the most played outbreak sim games.
7.9
929
188
3
players
6. The Fabulous Fear Machine
The Fabulous Fear Machine is a narrative-driven strategy game with a pulp horror style. As the Machine's new Master, you must sow fear and expand your influence by creating Legends, harvesting resources, manipulating events, and spying on your enemies. The Fabulous Fear Machine is a outbreak sim, horror and indie game developed by Fictiorama Studios and published by AMC Games. Released on October 04th 2023 has received 508 reviews of which 461 were positive and 47 were negative resulting in a rating of 8.5 out of 10. The game currently holds the #6 spot among the most played outbreak sim games.
8.5
461
47
2
players
Best deals on outbreak sim games on Steam
Discover fantastic savings with the best discounts on a variety of outbreak sim games available on Steam right now, updated on April 16th 2025. Looking for even more deals? Use the search filters to explore a wider range of discounted outbreak sim games.
1. Plague Inc: Evolved
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Plague Inc: Evolved is a strategy, simulation and outbreak sim game developed and published by Ndemic Creations. Released on February 18th 2016 has received 54,825 reviews of which 51,809 were positive and 3,016 were negative resulting in an impressive rating of 9.3 out of 10. Featuring a massive 70% discount, this game currently holds the #1 spot in the best deals for outbreak sim category.
9.3
51,809
3,016
-70%
14.79€
4.43€
2. Galacticare
Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams. Galacticare is a story rich, casual and medical sim game developed by Brightrock Games and published by CULT Games. Released on May 23rd 2024 has received 547 reviews of which 484 were positive and 63 were negative resulting in a rating of 8.3 out of 10. Thanks to its 30% discount, this game is now the #2 best deal in outbreak sim games.
8.3
484
63
-30%
28.99€
20.29€